期刊
TRENDS IN MICROBIOLOGY
卷 18, 期 12, 页码 543-551出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.09.003
关键词
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资金
- Spanish Ministerio de Ciencia e Innovacion [BFI2003 00405, BFU2006 00966, FIS PI060624, BFU2009 06958, FIPSE 360783 09]
- FP6 project [LSHB CT 03 503480]
The major pathway for HIV internalization in CD4+ T cells has been thought to be the direct fusion of virus and cell membranes, because the cell surface is the point of entry of infectious particles However, the exact contribution of endocytic pathways to the infection of CD4+ T lymphocytes is unknown, and the mechanisms involved in endocytosis of HIV particles are unclear Recent evidence suggests that endocytosis of cell-free and cell-associated virus particles could lead to effective virus entry and productive infections Such observations have, in turn, spurred a debate on the relevance of endosomal entry as a mechanism of escape from the immune system and HIV entry inhibitors In this paper, we review the endocytosis of HIV and discuss its role in HIV infection and pathogenesis
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