期刊
TRENDS IN MICROBIOLOGY
卷 17, 期 3, 页码 89-94出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2008.11.006
关键词
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资金
- Canadian Institutes of Health Research, the Natural Science and Engineering Research Council of Canada
- Canadian Foundation for Innovation
The emergence of multi-drug resistance and bacteria with increased virulence is a familiar refrain to the contemporary microbiologist. Although intense research over the past decade has ascribed much molecular detail to these processes, more esoteric questions remain: for example, why are some bacteria evolving increased virulence towards humans, what are the genes underpinning this virulence potential and what are the selective pressures that favor these traits? A holistic approach that considers the organismal biology of bacteria with their diverse hosts seems appropriate to begin to tackle such issues. As it happens, the type III secretion system is turning out to be a central player in the adaptation of both parasites and mutualists to diverse hosts. With this in mind, human interventions in agriculture, animal husbandry and even drug discovery that could influence the selection of bacteria with improved type III secretion system function should be critically appraised.
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