期刊
TRENDS IN MICROBIOLOGY
卷 16, 期 4, 页码 173-180出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2008.02.001
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI024656] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI024656, R01 AI024656-18, AI24656] Funding Source: Medline
The ability of bacterial pathogens to inhibit apoptosis in eukaryotic cells during infection is an emerging theme in the study of bacterial pathogenesis. Prevention of apoptosis provides a survival advantage because it enables the bacteria to replicate inside host cells. Bacterial pathogens have evolved several ways to prevent apoptosis by protecting the mitochondria and preventing cytochrome c release, by activating cell survival pathways, or by preventing caspase activation. This review summarizes the most recent work on bacterial antiapoptotic strategies and suggests new research that is necessary to advance the field.
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