期刊
TRENDS IN MICROBIOLOGY
卷 16, 期 2, 页码 44-47出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2007.12.004
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资金
- NIAID NIH HHS [R01 AI052281, R56 AI072490, R56 AI072490-01A1, R01 AI052281-05] Funding Source: Medline
To initiate infection, poliovirus must release its RNA genome into the cytoplasm of a target cell, a process called 'uncoating'. How this occurs has remained uncertain, despite studies over several decades. Two new studies re-address the question of poliovirus entry. The results suggest that poliovirus enters different cells by different mechanisms, and point to a role for virus-induced intracellular signals in the process.
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