期刊
TRENDS IN IMMUNOLOGY
卷 39, 期 10, 页码 848-858出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.08.008
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资金
- National Institutes of Health [R01-AI081759, R21-AI139576]
- Burroughs Wellcome Investigators in the Pathogenesis of Infectious Disease Award
- UPMC Children's Hospital of Pittsburgh Health System
Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological protection against viruses. These barriers utilize nonredundant mechanisms to suppress viral infections including the production of interferons (IFNs), which induce a strong antiviral state following receptor binding. However, whereas type I IFNs control infection systemically, type III IFNs (IFN-lambda s) control infection locally at barrier surfaces and are often preferentially induced by these cells. In this review we focus on the role of IFN-lambda at barrier surfaces, focusing on the respiratory and GI tracts, the BBB, and the placenta, and on how these IFNs act to suppress viral infections.
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