期刊
TRENDS IN IMMUNOLOGY
卷 35, 期 1, 页码 38-46出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.10.007
关键词
plasmacytoid dendritic cells; myeloid dendritic cells; cytotoxicity; TRAIL; granzyme B; antitumor therapy
类别
资金
- Netherlands Organization for Scientific Research (NWO ZonMW) [91776363]
- Netherlands Institute for Regenerative Medicine (NIRM) [FE50908]
- EU (ERC) [269019]
- Belgian Hematological Society
- Belgian Foundation against Cancer
- Belgian public utility foundation VOCATIO
- NWO
Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies.
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