期刊
TRENDS IN IMMUNOLOGY
卷 35, 期 11, 页码 549-561出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.08.007
关键词
HIV-1; antibodies; B cells; adaptive immunity; viruses
类别
资金
- European Research Council (ERC) [ERC-2013-StG 337146]
- G5 Institut Pasteur Program
- Milieu Interieur Program [ANR-10-LABX-69-01]
In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning, high-throughput sequencing, and structural biology methods have enabled the capture and thorough characterization of these exceptionally potent broadly neutralizing antibodies (bNAbs). Here, I review the recent findings in humoral responses to HIV-1, focusing on the interplay between naturally occurring bNAbs and the virus both at systemic and mucosa! levels. In this context, I discuss how an improved understanding of bNAb generation may provide invaluable insight into the fundamental mechanisms governing adaptive B cell responses to viruses, and how this knowledge is currently contributing to the development of vaccine and therapeutic strategies against HIV-1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据