期刊
TRENDS IN IMMUNOLOGY
卷 35, 期 1, 页码 32-37出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.10.002
关键词
hematopoietic stem cells; stem cell niche; mesenchymal stem cells; osteoblasts; CXCL12
类别
资金
- National Institutes of Health [HL60772]
Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the bone marrow. The stem cell niche is thought to provide signals that support key HSC properties, including self-renewal capacity and long-term multilineage repopulation ability. The stromal cells that comprise the stem cell niche and the signals that they generate that support HSC function are the subjects of intense investigation. Here, we review the complex and diverse stromal cell populations that reside in the bone marrow and examine their contribution to HSC maintenance. We highlight recent data suggesting that perivascular chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key cellular components of the stem cell niche in the bone marrow.
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