期刊
TRENDS IN IMMUNOLOGY
卷 35, 期 11, 页码 526-537出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.07.003
关键词
microbiota; immune system; vaccines; probiotics; malnutrition
类别
资金
- Canadian Institutes for Health and Research (CIHR)
- Michael Smith Foundation for Health Research (MSFHR)/Crohn's and Colitis Foundation of Canada
- CIHR
Studies of the relationship between the microbiome and the development and function of the immune system are demonstrating novel concepts that could significantly alter the way we treat disease and promote wellness. Several diseases, including inflammatory bowel disease, allergy/asthma, and diabetes, are associated with changes in composition of the microbiome. Recent findings suggest novel complex mechanisms by which the microbiome impacts immune cell development and differentiation. A major implication of these findings is that the composition of microbiome may ultimately affect vaccine efficacy. We explore here the potential role of the microbiome in vaccine responses in the context of our growing understanding of the relationship between the gastrointestinal microbiota, resident immune cell populations, and systemic immunity.
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