期刊
TRENDS IN IMMUNOLOGY
卷 34, 期 9, 页码 423-430出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.07.001
关键词
Gut microbiome; Mucosal regulatory T cells; Anti-inflammatory organisms; Proinflammatory (colitogenic organisms); Inflammatory Bowel Disease
类别
资金
- Intramural NIH HHS [ZIA AI000354-27] Funding Source: Medline
In the past 10 years it has become increasingly apparent that the gut microbiome has profound effects on the immune system to which it is juxtaposed, the mucosal immune system. Here, I explore recent studies in which the effects of the microbiota expand or facilitate anti-inflammatory or regulatory immunological machinery or which favor development of proinflammatory immunological machinery in this system. I then focus on how these opposing processes play out in inflammatory bowel disease (IBD); a disease in which normal immune homeostasis is disturbed and inflammation takes hold.
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