期刊
TRENDS IN IMMUNOLOGY
卷 34, 期 2, 页码 41-49出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2012.09.005
关键词
caspase; apoptosis; necroptosis; inflammation; immunity
类别
资金
- Canadian Institutes for Health Research (CIHR)
- Canada Foundation of Innovation
- Burroughs Wellcome Fund
- Canadian Cancer Society
- Fonds de Recherche en Sante du Quebec (FRSQ)
- FRSQ
- CIHR
- Strauss Foundation
Caspases are crucial for the execution of apoptotic cell death. However, caspase-1, the first identified mammalian caspase, was not discovered in the context of apoptosis, but rather as an enzyme that processes the proinflammatory cytokine interleukin (IL)-1 beta. More recently, additional nonapoptotic roles of apoptotic caspases have been uncovered. For example, caspase-8 can counteract necroptosis, an inflammatory mode of cell death induced by receptor-interacting protein (RIP)3. Here, we explore how caspases and their associated proteins and substrates mediate multiple cellular immune processes that extend beyond cell death. We focus on caspases-1, -8 and -11 because of the growing excitement in considering these caspases through the lens of regulators of immunity rather than primarily as arbiters of cell fate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据