期刊
TRENDS IN IMMUNOLOGY
卷 32, 期 10, 页码 493-503出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2011.06.011
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资金
- NHLBI NIH HHS [P01 HL056949, P01 HL056949-11] Funding Source: Medline
- NIAID NIH HHS [P01 AI078897, R01 AI069259-06, R01 AI069259, P01 AI078897-03] Funding Source: Medline
Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.
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