期刊
TRENDS IN IMMUNOLOGY
卷 32, 期 11, 页码 548-558出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2011.08.001
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- Intramural NIH HHS [ZIA AI000542-23] Funding Source: Medline
Defective ribosomal products (DRiPs) are a subset of rapidly degraded polypeptides that provide peptide ligands for major histocompatibility complex (MHC) class I molecules. Here, recent progress in understanding DRIP biogenesis is reviewed. These findings place DRiPs at the center of the MHC class I antigen processing pathway, linking immunosurveillance of viruses and tumors to mechanisms of specialized translation and cellular compartmentalization. DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity.
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