期刊
TRENDS IN IMMUNOLOGY
卷 31, 期 1, 页码 32-38出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.09.005
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资金
- National Institute of Health [AI068730, EB003968, GM62134, GM069736]
- Swedish Research Council [2006-5595, 15244]
- Swedish Research Council/Vinnova/Swedish Foundation [6076170]
- Natural Sciences Faculty, University of Kalmar, Sweden
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI068730] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003968] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062134, R24GM069736] Funding Source: NIH RePORTER
Biomaterials (e.g. polymers, metals, or ceramics), cell and cell cluster (e.g. pancreatic islets) transplantation are beginning to offer novel treatment modalities for some otherwise intractable diseases. The innate immune system is involved in incompatibility reactions that occur when biomaterials or cells are introduced into the blood circulation. In particular, the complement, coagulation and contact systems are involved in the recognition of biomaterials and cells, eliciting activation of platelets and leukocytes. Such treatments are associated with anaphylactoid and thrombotic reactions, inflammation, and rejection of biomaterials and cells, leading to treatment failures and adverse reactions. We discuss here the new technologies that are being developed to shield the biomaterial and cell surfaces from recognition by the innate immune system.
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