期刊
TRENDS IN IMMUNOLOGY
卷 30, 期 7, 页码 319-324出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.03.012
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类别
资金
- NTH ROT [AG01.8859, R01 AG028082, R01 AG026727, R21 AG031511]
- Research Center on Aging
- Canadian Institutes of Health Research [63149]
- University of Sherbrooke
- Canadian Institutes of Health Research
- Ralph and Marian C. Falk Medical Research Trust
Aging affects every innate immune cell, including changes in cell numbers and function. Defects in the function of some cells are intrinsic, whereas for other cells, defects are extrinsic and possibly the consequence of the complex interactions with other cell types or the environmental milieu that is altered with aging. Abnormal function contributes to worsened outcomes after injury or infection and leads to diseases observed in the elderly. Knowing the mechanisms responsible for the aberrant function of innate immune cells might lead to the development of therapeutic strategies designed to improve innate immunity in aged individuals. Herein, advances in the field of innate immunity and aging with a focus on neutrophils, macrophages and dendritic cells in laboratory animals are discussed.
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