期刊
TRENDS IN IMMUNOLOGY
卷 29, 期 2, 页码 91-97出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.11.004
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- NHLBI NIH HHS [HL 059842] Funding Source: Medline
- NIAID NIH HHS [AI 052733, AI 033142, AI 033774] Funding Source: Medline
A central dogma in immunology is that antibody specificity is solely the result of variable M-region interactions with an antigen. However, this view is not tenable in light of numerous reports that constant heavy (C-H) domains can affect binding affinity and specificity and V-region structure. Kinetic and thermodynamic proof for the occurrence of this phenomenon is now available. CH-region effects on affinity and specificity suggest new mechanisms for generating antibody diversity and polyreactivity (multispecificity) that impact current views on idiotype regulation, autoimmunity, and B cell selection and change our understanding of vaccine responses.
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