期刊
TRENDS IN GENETICS
卷 30, 期 3, 页码 85-94出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2014.01.001
关键词
microhomology; double-strand breaks; structural variation; genomic disorders; microhomology-mediated end joining; microhomology-mediated break-induced replication
资金
- 26 Astro Brain Tumour Fund
- Brain Tumour Action
- Rosetrees Trust
- The Brain Tumour Charity for research in the Sheer laboratory
- Rosetrees Trust [M168-F1] Funding Source: researchfish
Genomic structural variation, which can be defined as differences in the copy number, orientation, or location of relatively large DNA segments, is not only crucial in evolution, but also gives rise to genomic. disorders. Whereas the major mechanisms that generate structural variation have been well characterised, insights into additional mechanisms are emerging from the identification of short regions of DNA sequence homology, also known as microhomology, at chromosomal break-points. In addition, functional studies are elucidating the characteristics of microhomology-mediated pathways, which are mutagenic. Here, we describe the features and mechanistic models of microhomology-mediated events, discuss their physiological and pathological significance, and highlight recent advances in this rapidly evolving field of research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据