期刊
TRENDS IN GENETICS
卷 29, 期 5, 页码 318-327出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2013.01.004
关键词
disease genetics; mRNA metabolism; RNA-binding protein; interactome capture; RNA-binding domain; mass spectrometry; proteomics; gene set enrichment
资金
- European Research Council
- Virtual Liver Network of the German Ministry for Science and Education
- National Health and Medical Research Council of Australia
- Australian Research Council
RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating over 1100 proteins in RNA binding. Surprisingly, over 350 of these RBPs had no prior RNA binding-related annotation or domain homology. The datasets also contain many proteins that, when mutated, cause Mendelian diseases, prominently neurological, sensory, and muscular disorders and cancers. Disease mutations in these proteins occur throughout their domain architectures and many are found in non-classical RNA-binding domains and in disordered regions. In some cases, mutations might cause disease through perturbing previously unknown RNA-related protein functions. These studies have thus expanded our knowledge of RBPs and their role in genetic diseases. We also expect that mRNA interactome capture approaches will aid further exploration of RNA systems biology in varied physiological and pathophysiological settings.
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