期刊
TRENDS IN GENETICS
卷 29, 期 8, 页码 442-448出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2013.04.003
关键词
RNA binding proteins; nonsense-mediated mRNA decay; intron retention; RNA localization; post-transcriptional gene regulation
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [K99MH096807] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NIMH NIH HHS [K99 MH096807] Funding Source: Medline
Alternative pre-mRNA splicing determines the protein output of most neuronally expressed genes. Many examples have been described of protein function being modulated by coding changes in different mRNA isoforms. Several recent studies demonstrate that, through the coupling of splicing to other processes of mRNA metabolism, alternative splicing can also act as an on/off switch for gene expression. Other regulated splicing events may determine how an mRNA is utilized in its later cytoplasmic life by changing its localization or translation. These studies make clear that the multiple steps of post-transcriptional gene regulation are strongly linked. Together, these regulatory process play key roles in all aspects of the cell biology of neurons, from their initial differentiation, to their choice of connections, and finally to their function with mature circuits.
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