期刊
TRENDS IN GENETICS
卷 28, 期 9, 页码 427-435出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2012.04.002
关键词
-
资金
- Canadian Institutes for Health and Research [186007]
- National Institutes of Health [MH074127, MH088413]
- Krembil Foundation
- Canadian Institutes of Health Research fellowship
Understanding the origins of normal and pathological behavior is one of the most exciting opportunities in contemporary biomedical research. There is increasing evidence that, in addition to DNA sequence and the environment, epigenetic modifications of DNA and histone proteins may contribute to complex phenotypes. Inherited and/or acquired epigenetic factors are partially stable and have regulatory roles in numerous genomic activities, thus making epigenetics a promising research path in etiological studies of psychiatric disease. In this article, we review recent epigenetic studies examining the brain and other tissues, including those from individuals with schizophrenia (SCZ) and bipolar disorder (BPD). We also highlight heuristic aspects of the epigenetic theory of psychiatric disease and discuss the future directions of psychiatric epigenetics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据