期刊
TRENDS IN GENETICS
卷 26, 期 8, 页码 340-343出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2010.05.006
关键词
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资金
- National Institutes of Health [AG019787, NS058988]
- China Scholarship Council
- Deutsche Forschungsgemeinschaft [SFB TR3]
- Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Medical Research Council
- Wellbeing Initiative
- Russian Foundation for Basic Research [08-04-01651-, 10-04-00276-]
- Russian Ministry of Science and Education [P2442]
- Russian Science Support Foundation
- President of the Russian Federation [MK-5423.2008.4]
- Medical Research Council [G0800674, G0601943, MC_G0802536, G0601943B] Funding Source: researchfish
- MRC [G0601943, G0800674, MC_G0802536] Funding Source: UKRI
Perfect direct repeats and, in particular, the prominent 13 bp repeat, are thought to cause mitochondrial DNA (mtDNA) deletions, which have been associated with the aging process. Accordingly, individuals lacking the 13 bp repeat are highly prevalent among centenarians and overall number of perfect repeats in mammalian mitochondrial genomes negatively correlates with species' longevity. However, detailed examination of the distribution of mtDNA deletions challenges a special role of the 13 bp repeat in generating mtDNA deletions. Instead, deletions appear to depend on long and stable, albeit imperfect, duplexes between distant mtDNA segments. Furthermore, significant dissimilarities in breakpoint distributions suggest that multiple mechanisms are involved in creating mtDNA deletions.
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