期刊
TRENDS IN GENETICS
卷 25, 期 2, 页码 82-90出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2008.12.001
关键词
-
资金
- BBSRC
- MRC
- EU NoE The Epigenome, CellCentric
- Life Sciences Research Foundation
- BBSRC [BBS/E/B/0000M220] Funding Source: UKRI
- MRC [G0700098] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000M220] Funding Source: researchfish
- Medical Research Council [G0700098, G0300723B] Funding Source: researchfish
Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the existence of active demethylation has been known for a longer time in mammals, the means of achieving it remain murky and mammals lack counterparts to the plant demethylases. Several intriguing experiments have indicated, but not conclusively proven, that DNA repair is also a plausible mechanism for animal demethylation. Here, we examine what is known from flowering plants about the pathways and function of enzymatic demethylation and discuss possible mechanisms whereby DNA repair might also underlie global demethylation in mammals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据