期刊
TRENDS IN GENETICS
卷 25, 期 10, 页码 434-440出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2009.08.003
关键词
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资金
- NIH-supported Center for Biomedical Computing at the Brigham and Women's Hospital
- NATIONAL LIBRARY OF MEDICINE [U54LM008748] Funding Source: NIH RePORTER
Coordinated regulation of gene expression relies on transcription factors (TFs) binding to specific DNA sites. Our large-scale information-theoretical analysis of >950 TF-binding motifs demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations. Although bacterial TFs can recognize a specific DNA site in the genomic background, eukaryotic TFs exhibit widespread, nonfunctional binding and require clustering of sites to achieve specificity. We find support for this mechanism in a range of experimental studies and in our evolutionary analysis of DNA-binding domains. Our systematic characterization of binding motifs provides a quantitative assessment of the differences in transcription regulation in prokaryotes and eukaryotes.
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