期刊
TRENDS IN GENETICS
卷 24, 期 6, 页码 280-288出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2008.03.008
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资金
- Medical Research Council [G0400653] Funding Source: Medline
- Medical Research Council [G0400653] Funding Source: researchfish
- MRC [G0400653] Funding Source: UKRI
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA polymerase. This unusual structure provides a docking platform for factors involved in various co-transcriptional events. Recruitment of the appropriate factors at different stages of the transcription cycle is achieved through changing patterns of post-translational modification of the CTD repeats, which create a readable 'code'. A new phosphorylation mark both expands the CTD code and provides the first example of a CTD signal read in a gene type-specific manner. How and when is the code written and read? How does it contribute to transcription and coordinate RNA processing?.
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