期刊
TRENDS IN GENETICS
卷 24, 期 5, 页码 207-211出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2008.02.003
关键词
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The comparison of fully sequenced genomes enables the study of selective constraints that determine genome organisation. We show that, in fungi, adjacent divergently transcribed (<-->) genes are more conserved in orientation than convergent (-><-) or co-oriented (->->) gene pairs. Furthermore, the time divergent orientation of two genes is conserved correlates with the degree of their co-expression and with the likelihood of them being functionally related. The functional interactions of the proteins encoded by the conserved divergent gene pairs indicate a potential for protein function prediction in eukaryotes.
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