期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 29, 期 10, 页码 686-698出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2018.08.002
关键词
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资金
- DFG [SFB914 TP B08, SFB1123 TP A06, SFB1123 TP B05, SO876/6-1, SO876/11-1]
- Else Kroner Fresenius Stiftung
- Vetenskapsradet [2017-01762]
- FoFoLe program of the LMU Munich
- Fritz Thyssen Foundation
- Leducq Foundation
- EU's Horizon 2020 Research and Innovation Programme under Marie Sklodowska-Curie [675111]
- Swedish Research Council [2017-01762] Funding Source: Swedish Research Council
- Marie Curie Actions (MSCA) [675111] Funding Source: Marie Curie Actions (MSCA)
Altered nutritional behavior in Western societies has unleashed numerous metabolic disorders, intimately linked to profound disruptions of the immune system. Here we summarize how nutrition modulates innate immunity. We outline recent findings regarding nutrient signaling and we particularly focus on the collateral impact of nutrition on the microbiome and on the bile acid (BA) pool. We discuss how the integration of postprandial signals by the gut microbiota, along with the absorption routes of metabolites, differentially affects immune niches to orchestrate immune responses. Finally, we discuss the potential consequences of these signals in the light of trained immunity. A better understanding of nutrition signaling will permit the optimization of therapeutic and dietary strategies against the arising immune disorders.
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