期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 25, 期 10, 页码 502-508出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2014.03.004
关键词
C. elegans; metabolic network; gene regulatory network; gene expression; nutrient response; life history traits; nuclear hormone receptors; transcription; bacteria
资金
- National Institute of Health [DK068429]
Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control of metabolic enzymes. Here, we discuss recent insights regarding metazoan metabolic regulatory networks using the nematode Caenorhabditis elegans as a model, including the modular organization of metabolic gene regulatory networks, the prominent impact of diet on the transcriptome and metabolome, specialized roles of nuclear hormone receptors (NHRs) in responding to dietary conditions, regulation of metabolic genes and metabolic regulators by miRNAs, and feedback between metabolic genes and their regulators.
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