期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 25, 期 4, 页码 178-187出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2014.01.002
关键词
diabetes mellitus; complications; diabetic nephropathy; diabetic retinopathy; diabetic neuropathy; bone marrow; hematopoietic cells
资金
- US National Institutes of Health [P30-DK079638, T32-HL066991, R01-HL051586]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [23590378]
- Shiga University of Medical Science [1515503I]
- St. Luke's Medical Center, Houston, Texas
- Grants-in-Aid for Scientific Research [23590378] Funding Source: KAKEN
Diabetic complications encompass macrovascular events, mainly the result of accelerated atherosclerosis, and microvascular events that strike the eye (retinopathy), kidney (nephropathy), and nervous system (neuropathy). The traditional view is that hyperglycemia-induced dysregulated biochemical pathways cause injury and death of cells intrinsic to the organs affected. There is emerging evidence that diabetes compromises the function of the bone marrow (BM), producing a stem cell niche-dependent defect in hematopoietic stem cell mobilization. Furthermore, dysfunctional BM-derived hematopoietic cells contribute to diabetic complications. Thus, BM cells are not only a victim but also an accomplice in diabetes and diabetic complications. Understanding the underlying molecular mechanisms may lead to the development of new therapies to prevent and/or treat diabetic complications by specifically targeting these perpetrators.
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