期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 25, 期 11, 页码 567-575出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2014.06.009
关键词
integrins; cadherins; Wnt signaling; bone formation; bone repair; niches
资金
- Agence Nationale de la Recherche [ANR-2010-BLAN-1505-01]
- 7th Framework Programme Tabs (EC) [HEALTH-F2-2008-201099]
- Societe Francaise de Rhumatologie (Paris, France)
- Association Prevention et Traitement des Decalcifications (Paris, France)
- Fondation de l'Avenir pour la Recherche Appliquee (Paris, France) [ET9-521]
Cell-cell and cell-matrix interactions mediated by cell adhesion molecules are important mechanisms controlling cell fate and function. Here, we review recent advances in the implication of the cell adhesion molecules integrins and cadherins in the control of osteoblastogenesis and bone formation. We discuss emerging evidence indicating that signaling pathways mediated by integrins and cadherins and their crosstalk with the Wnt/beta-catenin signaling pathway regulate osteogenic differentiation and mechanotransduction. We also offer a comprehensive view of the mechanisms by which some integrins and cadherins control the differentiation of cells of the osteoblast lineage in bone marrow niches. Understanding how specific integrins or cadherins may promote osteogenic cell differentiation, bone formation, and repair may lead to novel therapeutic strategies.
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