期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 2, 页码 92-100出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.11.006
关键词
taste receptors; gastrointestinal hormones; sweet; bitter; umami; fatty acid
资金
- Flemish Foundation for Scientific Research [FWO G.0670.10]
- Methusalem grant from the University of Leuven
The release of gut hormones involved in the control of food intake is dependent on the acute nutritional status of the body, suggesting that chemosensory mechanisms are involved in the control of their release. G protein-coupled taste receptors similar to those in the lingual system, that respond to sweet, bitter, umami, and fatty acids, are expressed in endocrine cells within the gut mucosa, and coordinate, together with other chemosensory signaling elements, the release of hormones that regulate energy and glucose homeostasis. In health, these nutrient sensors are likely to function as inhibitors to excessive nutrient exposure, and their malfunction may be responsible for a variety of metabolic dysfunctions associated with obesity; they may thus be considered as new therapeutic targets.
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