期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 5, 页码 247-256出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.12.003
关键词
sarcopenia; mitochondria; protein metabolism; protein synthesis; aging
资金
- National Institutes of Health [UL1-RR-024150-01, AG09531, R01-DK41973, T32 DK007198, T32 DK007352-32]
- Mayo Foundation
- Murdock-Dole Professorship
Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据