期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 12, 页码 625-634出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.09.006
关键词
transcription; epigenonaics; coregulators; inflammation; metabolism; obesity
资金
- French National Agency of Research (ANR)
- Region Ile de France
- National Agency for Research (program 'Investments for the Future') [ANR-10-IAHU']
- Center for Biosciences
- Swedish Research Council
- Novo Nordisk Foundation
- Swedish Cancer Society
Chronic inflammation of adipose tissue is viewed as a hallmark of obesity and contributes to the development of type 2 diabetes and cardiovascular disease. According to current models, nutrient excess causes metabolic and structural changes in adipocytes, which initiate transcriptional programs leading to the expression of inflammatory molecules and the subsequent recruitment of immune cells. Recent advances in deciphering the underlying mechanisms revealed that key regulatory events occur at the genomic and epigenomic levels. Here we review these advances because they offer a better understanding of the mechanisms behind the complex obesogenic program in adipose tissue, and because they may help in defining new therapeutic strategies that prevent, restrict, and resolve inflammation in the context of obesity.
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