期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 3, 页码 129-136出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.10.008
关键词
hypercholesterolemia; atherosclerosis; hematopoietic stem and progenitor cells; monocytes; neutrophils
资金
- German Research Foundation [SO876/3-1, FOR809, SFB914 TPB08]
- German-Israeli Foundation
- FoFoLe Program within the Medical Faculty of the LMU Munich
- Else Kroner Fresenius Stiftung
- NWO
- National Institutes of Health [R01 HL095612]
Atherosclerosis is characterized by the progressive accumulation of lipids and leukocytes in the arterial wall. Leukocytes such as macrophages accumulate oxidized lipoproteins in the growing atheromata and give rise to foam cells, which can then contribute to the necrotic core of lesions. Lipids and leukocytes also interact in other important ways. In experimental models, systemic hypercholesterolemia is associated with severe neutrophilia and monocytosis. Recent evidence indicates that cholesterol-sensing pathways control the proliferation of hematopoietic stem-cell progenitors. Here we review some of the studies that are forging this particular link between metabolism and inflammation, and propose several strategies that could target this axis for the treatment of cardiovascular disease.
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