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AMPK: mediating the metabolic effects of salicylate-based drugs?

期刊

TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 10, 页码 481-487

出版社

ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.06.002

关键词

AMPK; aspirin; salicylate; inflammation; diabetes; cancer

资金

  1. Canada Research Chair in Metabolism and Obesity
  2. Canadian Institutes of Health Research
  3. Canadian Diabetes Association
  4. Wellcome Trust
  5. Cancer Research UK
  6. AstraZeneca
  7. Boehringer-Ingelheim
  8. GlaxoSmithKline
  9. Merck KgaA
  10. Janssen Pharmaceutica
  11. Pfizer
  12. Cancer Research UK [15101] Funding Source: researchfish

向作者/读者索取更多资源

Salicylates are among the oldest medicinal compounds known to humans, and have been used to reduce fever, pain, and inflammation. The major oral salicylates are aspirin and salsalate, both of which are rapidly metabolized to salicylate in vivo. Owing to its acetyl group, aspirin irreversibly inhibits cyclo-oxygenases and thus blocks platelet aggregation, whereas salsalate has been used for treatment of inflammatory diseases such as rheumatoid arthritis. Recently, beneficial effects of salicylates in type 2 diabetes and cancer have been proposed. This has led to renewed interest in understanding how these simple molecules have such diverse and multifaceted effects. Here we discuss the idea that AMP-activated protein kinase (AMPK) might mediate some effects of salicylate-based drugs, particularly by modulating cellular metabolism.

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