期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 7, 页码 324-331出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.03.005
关键词
T1DM; islet; GWAS; insulin
资金
- Margaret Q. Landenberger Foundation
- National Institutes of Health [K08-DK089117, 5-P01-DK-049210-15]
- Charles H. Humpton, Jr. Endowment
Type 1 diabetes mellitus (T1DM) is a chronic disease resulting from destruction of insulin-producing pancreatic beta cells. Genetic and environmental factors contribute to T1DM onset. Use of high-throughput DNA sequencing has allowed geneticists to perform genome-wide association studies (GWAS) to identify novel gene loci associated with T1DM. Interestingly, >50% of these genes encode products that are expressed in beta cells. These studies, coupled with emerging molecular evidence that beta cells are impaired by gain-of-function or loss-of-function of these loci, suggest an active role for the beta cell in eliciting its own demise. Although immune dysregulation plays a vital role in T1DM pathogenesis, understanding the mechanisms contributing to beta cell failure may lead to new strategies to preserve or improve beta cell function in patients with T1DM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据