期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 24, 期 3, 页码 153-163出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.10.009
关键词
transdifferentiation; beta cell regeneration; alpha cell hyperplasia; GLP-1-derived peptides
资金
- Juvenile Diabetes Research Foundation
- American Diabetes Association
- Novo Nordisk
- Merck Company
The alpha cells that coinhabit the islets with the insulin-producing beta cells have recently captured the attention of diabetes researchers because of new breakthrough findings highlighting the importance of these cells in the maintenance of beta cell health and functions. In normal physiological conditions alpha cells produce glucagon but in conditions of beta cell injury they also produce glucagon-like peptide-1 (GLP-1), a growth and survival factor for beta cells. In this review we consider these new findings on the functions of alpha cells. Alpha cells remain somewhat enigmatic inasmuch as they now appear to be important in the maintenance of the health of beta cells, but their production of glucagon promotes diabetes. This circumstance prompts an examination of approaches to coax alpha cells to produce GLP-1 instead of glucagon.
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