期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 23, 期 1, 页码 1-8出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2011.10.005
关键词
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资金
- National Institutes of Health
- Institut de la Sante et de la Recherche Medicale (France)
- Sirtris Pharmaceutical Inc.
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM081634] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R21AG033888, R21AG041504] Funding Source: NIH RePORTER
Circadian rhythms occur with a periodicity of approximately 24 h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders.
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