期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 23, 期 7, 页码 351-363出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.05.001
关键词
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资金
- Swiss National Science Foundation
- National Research Center Frontiers in Genetics
- Sinergia program
- 7th Framework Programme of the European Commission (TORNADO)
- Bonizzi Theler Foundation
Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects genes controlling vital processes. Among them, the peroxisome proliferator-activated receptors (PPARs) have emerged as links between lipids, metabolic diseases, and innate immunity. PPARs are activated by fatty acids and their derivatives, many of which also signal through membrane receptors, thereby creating a lipid signaling network between the cell surface and the nucleus. Tissues that play a role in whole-body metabolic homeostasis, such as adipose tissue, liver, skeletal muscle, intestines, and blood vessel walls, are prone to inflammation when metabolism is disturbed, a complication that promotes type 2 diabetes and cardiovascular disease. This review discusses the protective roles of PPARs in inflammatory conditions and the therapeutic anti-inflammatory potential of PPAR ligands.
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