期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 23, 期 7, 页码 319-325出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.03.004
关键词
-
资金
- National Institutes of Health [DK077086, HL097738]
- American Diabetes Association
- American Heart Association
Nutrient and energy metabolism in mammals exhibits a strong diurnal rhythm that aligns with the body clock. Circadian regulation of metabolism is mediated through reciprocal signaling between the clock and metabolic regulatory networks. Recent work has demonstrated that autophagy is rhythmically activated in a clock-dependent manner. Because autophagy is a conserved biological process that contributes to nutrient and cellular homeostasis, its cyclic induction may provide a novel link between clock and metabolism. This review discusses the mechanisms underlying circadian autophagy regulation, the role of rhythmic autophagy in nutrient and energy metabolism, and its implications in physiology and metabolic disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据