期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 22, 期 8, 页码 333-343出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2011.04.004
关键词
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资金
- Center for Biosciences
- Novo Nordisk Foundation
- Swedish Research Council [522-2008-3745]
- CODDIM (Cardiovasculaire Obesite Diabete Domaine d'Interet Majeur)
The acute phase response (APR) classically refers to the rapid reprogramming of gene expression and metabolism in response to inflammatory cytokine signaling. As components of the innate immune system, hepatocyte-derived acute phase proteins (APPs) play a central role in restoring tissue homeostasis. Recently, an intriguing 'metaflammatory' facet of the APR became evident with chronically elevated APP levels being connected to metabolic syndrome disorders. The causality of these connections is unclear but could relate to adverse metabolic and inflammatory disturbances, particularly those affecting lipoprotein properties, cholesterol metabolism and atherogenesis. Here we review these aspects with an emphasis on the emerging importance of lipid-sensing nuclear receptors (LXRs, LRH-1, PPARs), in conjunction with anti-inflammatory transrepression pathways, as physiological and pharmacological relevant modulators of the APR.
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