期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 21, 期 4, 页码 214-222出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2009.12.007
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资金
- NIEHS NIH HHS [R01 ES012974-04, R01 ES012974-07, R01 ES012974] Funding Source: Medline
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES012974] Funding Source: NIH RePORTER
The ability of environmental factors to promote a phenotype or disease state not only in the individual exposed but also in subsequent progeny for successive generations is termed transgenerational inheritance. The majority of environmental factors such as nutrition or toxicants such as endocrine disruptors do not promote genetic mutations or alterations in DNA sequence. However, these factors do have the capacity to alter the epigenome. Epimutations in the germline that become permanently programmed can allow transmission of epigenetic transgenerational phenotypes. This review provides an overview of the epigenetics and biology of how environmental factors can promote transgenerational phenotypes and disease.
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