期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 21, 期 2, 页码 104-110出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2009.09.007
关键词
-
资金
- FHSJ (Fondation de l'Hopital Ste-Justine)
- FRSQ (Fonds de la Recherche en Sante du Quebec)
- GRUM (Groupe de Recherche sur le Medicament de l'Universite de Montreal)
- CIHR (Canadian Institutes of Health Research)
- NSERC (Natural Sciences and Engineering Research Council of Canada)
- Cancer Research Society Inc.
- Canadian Foundation for Innovation
From classical gland-based endocrinology to nuclear hormone receptor biology, tremendous progress has been made in our understanding of hormone responses underlying cellular communication. Estrogen elicits a myriad of biological processes in reproductive and peripheral target tissues through its interaction with the estrogen receptors ER alpha and ER beta. However, our knowledge of estrogen-dependent and independent action has mainly focused on ER alpha, leaving the role of ER beta obscure. This review discusses our current understanding of ER beta function and the emerging role of intracellular signals that act upon and achieve estrogen-like effects through phosphorylation of ER beta protein. Improving our understanding of how cellular determinants impact estrogen receptor actions will likely lead to treatment strategies for related endocrine diseases affecting women's health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据