期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 20, 期 9, 页码 452-459出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2009.05.007
关键词
-
资金
- Juvenile Diabetes Research Foundation [3-2004-276, 10-2007-86]
Maintenance of homeostalsis during environmental flux requires constant metabolic adjustment, achieved partly through the fine regulation of gene expression. MicroRNAs are key players in this regulatory milieu; they have been implicated in regulating gene expression within several metabolically active tissues including the endocrine pancreas, liver and adipose tissue. Recent studies, for example, implicate miR-375 in pancreatic islet cell viability and function, and removal or overexpression of miR-375 profoundly affects glucose metabolism. In the liver, miR-122 is important for normal lipid metabolism. In fact, misexpression of miRNAs can occur in some diseases, suggesting that restoring miRNA expression is a potential therapeutic approach for both metabolic syndrome and diabetes.
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