期刊
TRENDS IN COGNITIVE SCIENCES
卷 17, 期 3, 页码 111-120出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2013.01.001
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资金
- CIHR
- NSERC
- NSF
- Down Syndrome Research and Treatment Foundation
- Research Down Syndrome
- Fondation Lejeune
- Thrasher Research Fund
Although the biological bases of forgetting remain obscure, the consensus among cognitive psychologists emphasizes interference processes, rejecting decay in accounting for memory loss. In contrast to this view, recent advances in understanding the neurobiology of long-term memory maintenance lead us to propose that a brain-wide well-regulated decay process, occurring mostly during sleep, systematically removes selected memories. Down-regulation of this decay process can increase the life expectancy of a memory and may eventually prevent its loss. Memory interference usually occurs during certain active processing phases, such as encoding and retrieval, and will be stronger in brain areas with minimal sensory integration and less pattern separation. In areas with efficient pattern separation, such as the hippocampus, interference-driven forgetting will be minimal, and, consequently, decay will cause most forgetting.
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