期刊
TRENDS IN COGNITIVE SCIENCES
卷 16, 期 3, 页码 181-188出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2012.02.001
关键词
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资金
- National Institute of Mental Health [R01MH083246, R01MH081218, BRAINS R01MH094639, R01AG032088]
- National Institute of Child Health and Human Development [R01HD065282]
- Brain and Behavior Research Foundation
- Autism Speaks and the Stavros Niarchos Foundation
The functional MRI (fMRI) community has zealously embraced resting state or intrinsic functional connectivity approaches to mapping brain organization. Having demonstrated their utility for charting the large-scale functional architecture of the brain, the field is now leveraging task-independent methods for the investigation of phenotypic variation and the identification of biomarkers for clinical conditions. Enthusiasm aside, questions regarding the significance and validity of intrinsic brain phenomena remain. Here, we discuss these challenges and outline current developments that, in moving the field toward discovery science, permit a shift from cartography toward a mechanistic understanding of the neural bases of variation in cognition, emotion and behavior.
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