期刊
TRENDS IN COGNITIVE SCIENCES
卷 15, 期 12, 页码 592-600出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2011.10.003
关键词
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资金
- NIH [DP20D002002, 1R01NS075421, 1R01DA029639, 1RC1MH088182, 1RC2DE020919, 1R01NS067199, 1R43NS070453]
- NSF [EFRI 0835878, DMS 0848804, DMS 1042134]
- Benesse Foundation
- Jerry and Marge Burnett
- Department of Defense
- Harvard/MIT Joint Grants Program in Basic Neuroscience
- Human Frontiers Science Program
- MIT Alumni Class Funds
- MIT Intelligence Initiative
- MIT McGovern Institute
- McGovern Institute
- MIT Media Lab
- MIT
- NARSAD
- Paul Allen Distinguished Investigator Award
- Alfred P. Sloan Foundation
- SFN Research Award for Innovation in Neuroscience
- Wallace H. Coulter Foundation
- Directorate For Engineering
- Emerging Frontiers & Multidisciplinary Activities [0835878] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1053233] Funding Source: National Science Foundation
In order to understand how the brain generates behaviors, it is important to be able to determine how neural circuits work together to perform computations. Because neural circuits are made of a great diversity of cell types, it is critical to be able to analyze how these different kinds of cell work together. In recent years, a toolbox of fully genetically encoded molecules has emerged that, when expressed in specific neurons, enables the electrical activity of the targeted neurons to be controlled in a temporally precise fashion by pulses of light. We describe this optogenetic toolbox, how it can be used to analyze neural circuits in the brain and how optogenetics is impacting the study of cognition.
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