期刊
TRENDS IN COGNITIVE SCIENCES
卷 14, 期 6, 页码 268-276出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2010.04.002
关键词
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资金
- NIDA [RO1 DA027764]
- MIH [MH072279]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R21MH072279] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA027764] Funding Source: NIH RePORTER
Learned fear is a process allowing quick detection of associations between cues in the environment and prediction of imminent threat. Adaptive function in a changing environment, however, requires organisms to quickly update this learning and have the ability to hinder fear responses when predictions are no longer correct. Here we focus on three strategies that can modify conditioned fear, namely extinction, reversal and regulation of fear, and review their underlying neural mechanisms. By directly comparing neuroimaging data from three separate studies that employ each strategy, we highlight overlapping brain structures that comprise a general circuitry in the human brain. This circuitry potentially enables the flexible control of fear, regardless of the particular task demands.
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