期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 7, 页码 400-406出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.03.003
关键词
amino acid sensing; GATOR complex; Ragulator; Rag GTPases; folliculin
类别
资金
- National Institutes of Health [CA103866, AI47389]
- Department of Defense [W81XWH-07-0448]
The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of Rags (Ras-related GTPases) and Ragulator v-ATPase, GATOR (GAP activity towards Rags), and folliculin (FLCN) complexes. Increased understanding of this pathway will not only provide insight into growth control but also into the human pathologies triggered by its deregulation.
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