期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 3, 页码 188-197出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.10.001
关键词
centrosomes; cilia; pericentriolar material; super-resolution microscopy; mitosis; cell cycle
类别
资金
- NIGMS NIH HHS [R01 GM031627] Funding Source: Medline
- NIH HHS [DP2 OD008479] Funding Source: Medline
The centrosome influences the shape, orientation and activity of the microtubule cytoskeleton. The pericentriolar material (PCM), determines this functionality by providing a dynamic platform for nucleating microtubules and acts as a nexus for molecular signaling. Although great strides have been made in understanding PCM activity, its diffraction-limited size and amorphous appearance on electron microscopy (EM) have limited analysis of its high-order organization. Here, we outline current knowledge of PCM architecture and assembly, emphasizing recent super-resolution imaging studies that revealed the PCM has a layered structure made of fibers and matrices conserved from flies to humans. Notably, these studies debunk the long-standing view of an amorphous PCM and provide a paradigm to dissect the supramolecular organization of organelles in cells.
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