期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 11, 页码 712-723出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.08.010
关键词
single cell; epigenetics; live cell; epigenomics; microfluidics
类别
资金
- Fondation pour la Recherche Medicale
- Agence Nationale de Recherche (CoreAc), La Ligue National Contre La Cancer (Equipe Labellise)
- European Research Council (ERC)
Mechanistically, how epigenetic states are inherited through cellular divisions remains an important open question in the chromatin field and beyond. Defining the heritability of epigenetic states and the underlying chromatin-based mechanisms within a population of cells is complicated due to cell heterogeneity combined with varying levels of stability of these states; thus, efforts must be focused toward single-cell analyses. The approaches presented here constitute the forefront of epigenetics research at the single-cell level using classic and innovative methods to dissect epigenetics mechanisms from the limited material available in a single cell. This review further outlines exciting future avenues of research to address the significance of epigenetic heterogeneity and the contributions of microfluidics technologies to single-cell isolation and analysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据